The Role of BAFF in B cell Biology and Autoimmunity

In healthy individuals, B cell development and maturation is tightly regulated, however this delicate balance is disrupted in autoimmune disease, where B cell dysfunction can lead to a loss of selftolerance. Disrupted B-cell maturation and function and is implicated in several autoimmune diseases, including system lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), Sjögren's Syndrome (SS), and Graves' Disease, and as a result significant research has focused on understanding the mechanisms governing B-cell maturation (Pillai, Mattoo et al. 2011, Bluml, McKeever et al. 2013).  more...

Kingfisher Biotech offers a growing number of BAFF recombinant proteins.