Chicken Chemokines

Recombinant chicken CCL4 (a.k.a. MIP-1 beta) and CCL20 (a.k.a. LARC) are now available from Kingfisher Biotech (www.kingfisherbiotech.com). Both proteins are members of the CC chemokine family. CC chemokines induce the migration of monocytes and other cell types such as NK cells and dendritic cells. An example of a CC chemokine is monocyte chemoattractant protein-1 (MCP-1 or CCL2) which induces monocytes to leave the bloodstream and enter the surrounding tissue to become tissue macrophages. CC chemokines induce cellular migration by binding to and activating CC chemokine receptors, ten of which have been discovered to date and called CCR1-10. These receptors are expressed on the surface of different cell types allowing their specific attraction by the chemokines. A CC chemokine that attracts lymphocytes is CCL28, which is chemoattractant to T cells and B cells that express the chemokine receptor CCR10. This chemokine can also attract eosinophils that express CCR3. CCL5 (or RANTES) attracts cells such as T cells, eosinophils and basophils that express the receptor CCR5.