IL-17A is a member of the IL-17 family, which is comprised of 6 members [IL-17A,
IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F]. IL-17 family
members are involved in numerous immune regulatory functions, including inducing
and mediating proinflammatory responses and allergic responses. Il-17 induces
the production of many other cytokines (IL-6, G-CSF, GM-CSF, IL-1beta, TGF-beta,
and TNF-alpha), chemokines, including IL-8 (CXCL8), GRO-alpha (CXCL1) and MCP-1
(CCL2) and prostaglandins from many cell types (fibroblasts, endothelial cells,
epithelial cells, keratinocytes and macrophages). Kingfisher Biotech has a growing portfolio of IL-17A products across many species.