Kingfisher Biotech’s Chicken IL-21 Protein Activity Confirmed by an Independent Lab.

IL-21 is a member of the type I cytokine family. Other members of the family include IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells.

Kingfisher Biotech’s chicken IL-21 protein has been shown to be a superior product for use in cell culture. The activity of chicken IL-21 was confirmed by an independent testing laboratory. The biological activity of chicken IL-21 was measured in a cell proliferation assay using chicken spleen lymphocytes. Recombinant chicken IL-21 induced proliferation in a dose-dependent manner from 7.8 ng/mL-62.5 ng/mL

Chicken IL-21 protein was produced in yeast without the use of tags. Proteins produced in yeast are naturally endotoxin free, properly folded, biologically active, and may be post-translationally modified. Many scientists find that these properties make proteins produced in yeast preferable over E. coli-produced proteins.

Chiicken IL-21 is lyophilized, available in convenient sizes (5, 25 and 100 micrograms) and in-stock ready to ship. Additional information, including product specifications and ordering information can be found at http://www.kingfisherbiotech.com.

Kingfisher Biotech is focused on providing kits and reagents to the animal health and animal model research community. Currently, the Kingfisher Biotech product portfolio contains over 750 products. Kingfisher Biotech products are supplied for research applications. They are not intended for medicinal, diagnostic or therapeutic use.