Wednesday, January 13, 2016

Chicken IL-6 Do-It-Yourself ELISA

The Chicken IL-6 Do-It-Yourself ELISA (Cat# DIY1115C-003) contains capture antibody, prottein standard, and detection antibody for development of a Chicken IL-6 ELISA. The antibodies have been determined to function in an ELISA with the standard provided. Components may also be purchased separately.

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. The role of IL-6 as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.

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