Annexins are important in various cellular and physiological
processes such as providing a membrane scaffold, which is relevant to changes
in the physical shape of the cell. Annexin proteins have been shown to be
involved in trafficking and organization of vesicles, exocytosis, endocytosis
and also calcium ion channel formation. Annexin proteins are not exclusively
intracellular protein: Annexin proteins are also found in the extracellular
space and have been linked to several processes fibrinolysis, coagulation,
inflammation and apoptosis. Annexin proteins are all capable of binding
negatively charged phospholipids in a calcium dependent manner and contain a 70
amino acid repeat sequence called an annexin repeat.
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