APRIL Homology Across Species

APRIL is a member of the TNF ligand family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important role for APRIL in the long-term survival of plasma cells in the bone marrow. Mice deficient in APRIL showed a reduced ability to support plasma cell survival. APRIL may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM.

Kingfisher Biotech is in the process of making recombinant APRIL from several species commercially available. Watch www.kingfisherbiotech.com for more information.