Bovine CD40 Ligand ELISA

Kingfisher Biotech's Bovine CD40 Ligand Do-It-Yourself ELISA (Catalog # DIY1211B-003) contains capture antibody, protein standard, and detection antibody for development of a CD40 Ligand ELISA. The antibodies have been determined to function in an ELISA with the standard provided.

CD40 Ligand (CD40LG) is a transmembrane protein that is a member of the TNF superfamily. In addition to existing in a membrane bound form, CD40LG can also be released as a soluble molecule (sCD40LG), which has been shown to have biological functions.

CD40 interacts with CD40 ligand (aka CD40LG, TNFSF5 or CD154), which is predominantly expressed on activated CD4+ T-cells. CD40LG is transiently expressed on activated T-cells and plays a crucial role in B-cell function. Activated T-cells expressing CD40LG can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines. The transient expression of CD40LG allows T-cells to stimulate selected CD40-bearing cells to participate in the immune response. 

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