IL-34: The brains behind CSF-1R pathology in the brain and skin?

In humans, loss or gain of function in CSF-1R has been associated with many inflammatory conditions and cancers, due to its role in the maintenance of mononuclear phagocytes. In particular, the CSF-1R ligand IL-34 plays a key role in maintaining the tissue resident macrophages of the skin and brain, thus being critical to antimicrobial and other inflammatory responses at these sites. IL-34, along with CSF-1, has also been implicated in the inflammation of rheumatoid arthritis and Sjögrens, as well as a poor prognosis in many malignancies. more...

CCL2 Homology Across 8 Species

Chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemotactic protein-1 (MCP-1), is a small cytokine belonging to the CC chemokine family. There are at least 27 distinct members of the C-C subgroup reported for mammals. They are characterized by two adjacent cysteines. CCL2 (MCP-1) recruits monocytes, memory T cells, and dendritic cells to sites of tissue injury and infection. CCL2 (MCP-1) is implicated in pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis.

MCP-1/CCL2 Homology Across Species

Kingfisher Biotech has Bovine CCL2, Canine CCL2, Equine CCL2, Guinea Pig CCL2, Rabbit CCL2, and Swine CCL2 products, including proteins, antibodies and ELISA VetSets.