Emerging Roles of IL-8 in Cancer Etiology

IL-8 exerts its tumorigenic effects through both autocrine and paracrine signaling. Secretion of IL-8 by tumor cells can enhance cell survival and proliferation of the cancer cells through autocrine signaling. IL-8 also plays an important role in the tumor microenvironment, which is composed of a diverse group of cells including fibroblasts, endothelial cells, dendritic cells, and tumor-associated macrophages. A complex network of cytokines, chemokines, and other inflammatory molecules drives communication between the microenvironment and the malignant tumor cells (Todorovic-Rakovic and Milovanovic, 2013). Importantly, IL-8 is implicated in the initiation of leukocyte infiltration, neovascularization, and angiogenesis, all processes that precede invasion and metastasis of tumor cells. Cancer cells secrete IL-8, triggering the infiltration of leukocytes to the site of chemokine production. Leukocytes in turn secrete cytokines and growth factors promoting angiogenesis and cell survival (Gales et al., 2013). more...

Kingfisher Biotech offers many IL-8 products, including recombinant proteins, antibodies, and ELISAs.

IL-34: The brains behind CSF-1R pathology in the brain and skin?

In humans, loss or gain of function in CSF-1R has been associated with many inflammatory conditions and cancers, due to its role in the maintenance of mononuclear phagocytes. In particular, the CSF-1R ligand IL-34 plays a key role in maintaining the tissue resident macrophages of the skin and brain, thus being critical to antimicrobial and other inflammatory responses at these sites. IL-34, along with CSF-1, has also been implicated in the inflammation of rheumatoid arthritis and Sjögrens, as well as a poor prognosis in many malignancies. more...