Monday, October 31, 2016
Monday, October 3, 2016
Rabbit C3a Do-It-Yourself ELISA, ≤10 Plates
The Rabbit C3a (Complement Component 3a) Do-It-Yourself ELISA (Cat# DIY1220U-003) contains capture antibody, protein standard, and detection antibody for development of a Rabbit C3a ELISA. The antibodies have been determined to function in an ELISA with the standard provided.
C3a is an effector molecule of both the classical and alternative complement pathways for a broad range of functions including T cell activation and survival, angiogenesis stimulation, chemotaxis, mast cell degranulation, and macrophage activation. C3a produces both pro- and anti-inflammatory responses. C3a, a 77 amino acid long anaphylatoxin, is produced when C3 convertases act on the N-terminal chain of the C3 protein. The activation of the C3 protein fragments it into two proteins. The smaller protein, C3a, promotes an inflammatory reaction while the larger, called C3b, binds to the surface of many microbial cells. The binding of C3a to the specific G protein-coupled receptor, C3aR, has been shown to be involved in several diseases such as rheumatoid arthritis, septic shock syndrome, age-related macular degeneration, and asthma. The immune response, initiated by C3a, acts by stimulating mast cell degranulation. Inhibiting the binding of C3a to C3aR with antagonists, such as diiminoisoindolines, diminishes the inflammatory response by disrupting the cascade. In many cases, it has been shown to be strong enough to counteract the pro-inflammatory effects of C5a.
You can find more products for animal health and animal model research at the Kingfisher Biotech website.
C3a is an effector molecule of both the classical and alternative complement pathways for a broad range of functions including T cell activation and survival, angiogenesis stimulation, chemotaxis, mast cell degranulation, and macrophage activation. C3a produces both pro- and anti-inflammatory responses. C3a, a 77 amino acid long anaphylatoxin, is produced when C3 convertases act on the N-terminal chain of the C3 protein. The activation of the C3 protein fragments it into two proteins. The smaller protein, C3a, promotes an inflammatory reaction while the larger, called C3b, binds to the surface of many microbial cells. The binding of C3a to the specific G protein-coupled receptor, C3aR, has been shown to be involved in several diseases such as rheumatoid arthritis, septic shock syndrome, age-related macular degeneration, and asthma. The immune response, initiated by C3a, acts by stimulating mast cell degranulation. Inhibiting the binding of C3a to C3aR with antagonists, such as diiminoisoindolines, diminishes the inflammatory response by disrupting the cascade. In many cases, it has been shown to be strong enough to counteract the pro-inflammatory effects of C5a.
You can find more products for animal health and animal model research at the Kingfisher Biotech website.
Friday, September 23, 2016
Bovine CD40 Ligand ELISA
Kingfisher Biotech's Bovine CD40 Ligand Do-It-Yourself ELISA (Catalog # DIY1211B-003) contains capture antibody, protein standard, and detection antibody for development of a CD40 Ligand ELISA. The antibodies have been determined to function in an ELISA with the standard provided.
CD40 Ligand (CD40LG) is a transmembrane protein that is a member of the TNF superfamily. In addition to existing in a membrane bound form, CD40LG can also be released as a soluble molecule (sCD40LG), which has been shown to have biological functions.
CD40 interacts with CD40 ligand (aka CD40LG, TNFSF5 or CD154), which is predominantly expressed on activated CD4+ T-cells. CD40LG is transiently expressed on activated T-cells and plays a crucial role in B-cell function. Activated T-cells expressing CD40LG can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines. The transient expression of CD40LG allows T-cells to stimulate selected CD40-bearing cells to participate in the immune response.
You can find more products for animal health and animal model research at the Kingfisher Biotech website.
CD40 Ligand (CD40LG) is a transmembrane protein that is a member of the TNF superfamily. In addition to existing in a membrane bound form, CD40LG can also be released as a soluble molecule (sCD40LG), which has been shown to have biological functions.
CD40 interacts with CD40 ligand (aka CD40LG, TNFSF5 or CD154), which is predominantly expressed on activated CD4+ T-cells. CD40LG is transiently expressed on activated T-cells and plays a crucial role in B-cell function. Activated T-cells expressing CD40LG can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines. The transient expression of CD40LG allows T-cells to stimulate selected CD40-bearing cells to participate in the immune response.
You can find more products for animal health and animal model research at the Kingfisher Biotech website.
Swine SCF Recombinant Protein
SCF, often known as Kit Ligand, KITL or KITLG, is involved in pathways that control the regulation of cell survival, migration and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, and melanogenesis. SCF binding to the receptor-type protein-tyrosine kinase KIT, induces a cell signaling pathway that activates several other cell signaling pathways, including PIK3R1/AKT1, GRB2, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1, and STAT signaling events. The effects of SCF on these secondary pathways further allow it to play a role in many or the major cellular processes. The SCF, of most vertebrates, has a soluble form as well as the membrane bound type I receptor form. Mutations in the SCF pathway may result in a broad range of abnormalities including anemia, and sterility. SCF and KIT interaction has been shown to promote the growth of cancer cells and organoids in culture, and xenograft tumors in mice. SCF is being utilized in many animal model systems, from metastasis research in breast tumor-bearing arthritic mice to the genetic linkage to de-pigmentation in pigs. Interestingly, a second SCF pathway was retained in zebrafish, after a whole genome duplication, and is now undergoing divergent evolution.
Kingfisher Biotech's Swine SCF recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. It has a predicted molecular weight of 18.7 kDa.
Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species, including bovine, canine, caprine, chicken, dolphin, equine, feline, guinea pig, hamster, human, mouse, ovine, rabbit, rat, swine, and turkey. We will continue to add species as our customer request specific reagents for their research. Currently, we offer over 1200 recombinant proteins, polyclonal antibodies, monoclonal antibodies and ELISA kits for animal health and animal model research. Our products are primarily cytokines, chemokines, interferons, and growth factors. Our product development queue is filled mainly by customer requests. If there is a product that you are looking for and can't find, please send us an email.
Kingfisher Biotech's Swine SCF recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. It has a predicted molecular weight of 18.7 kDa.
Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species, including bovine, canine, caprine, chicken, dolphin, equine, feline, guinea pig, hamster, human, mouse, ovine, rabbit, rat, swine, and turkey. We will continue to add species as our customer request specific reagents for their research. Currently, we offer over 1200 recombinant proteins, polyclonal antibodies, monoclonal antibodies and ELISA kits for animal health and animal model research. Our products are primarily cytokines, chemokines, interferons, and growth factors. Our product development queue is filled mainly by customer requests. If there is a product that you are looking for and can't find, please send us an email.
Tuesday, September 13, 2016
Swine IL-28B Recombinant Protein
IL-28B, IL-28A, and IL-29 are three closely related IFN-lambda cytokines that can be induced by viral infection that induce signaling through the Jak/STAT pathway. IL-28B, and other IFN-lambda cytokines, are well established as having several antiviral and anti-cancer activities. IFN-lambda, restricts virus from spreading into the brain and plays a major role in chronic viral infections found in the gastrointestinal tract. IL-28B, like other IFN-lambda cytokines, modulates innate and adaptive immunity, autoimmunity, and tumor progression. Unlike type I IFNs, which are able to stimulate most cell types, IL-28B, along with the other IFN-lambda cytokines, stimulation appears to be limited to dendritic cells and some tumor cell lines. Due to the affect IL-28B has on the adaptive immune system, it has gained much interest as an immunotherapeutic agent for treatment of allergic asthma. The IL-28 cytokines control T cell responses in vivo through the modulation of lung CD11c(+) DC function in experimental allergic asthma animal models. IFN-lambda cytokines, including IL-28B, have been shown to interact with a heterodimeric, class II cytokine receptor that consists of the IL-10 receptor, beta (IL-10RB) and the IL-28 receptor, alpha (IL-28RA) subunits. The promiscuous IL-10RB subunit is also common to IFN-alpha/beta family members, but the IL-28RA subunit is specific for the IFN-lambda cytokines, IL-28B, IL-28A, and IL-29.
Kingfisher Biotech offers Swine IL-28B in three sizes - 5 UG, 25 UG, and 100 UG.
Kingfisher Biotech offers Swine IL-28B in three sizes - 5 UG, 25 UG, and 100 UG.
Tuesday, August 16, 2016
Oncostatin M Proteins
OSM (Oncostatin M) is a secreted cytokine involved in homeostasis and most chronic illnesses. OSM, a member of the IL-6 (gp130) family of proteins, inhibits the proliferation of a number of tumor cell lines and plays a significant role in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. Of all IL-6-type cytokines studied so far, OSM displays the broadest signaling profile. LIF and OSM proteins activate the JAK/STAT pathway, the MAPK protein kinases ERK1 and ERK2, the stress-activated protein kinases p38 and c-Jun N-terminal kinase (JNK), the phosphatidylinositol-3-kinase (PI3K) AKT pathway and protein kinase C delta (PRKCD). In addition, OSM exhibits many other effects by regulating the production of other cytokines including IL-6, G-CSF and GM-CSF in endothelial cells. OSM may be a tumor promoter that will provide a potential target for antiangiogenic therapy.
Kingfisher Biotech's current portfolio of Oncostatin products, includes bovine and canine recombinant proteins with more in the development queue.
Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species, including bovine, canine, caprine, chicken, dolphin, equine, feline, guinea pig, hamster, human, mouse, ovine, rabbit, rat, swine, and turkey. We will continue to add species as our customer request specific reagents for their research. Currently, we offer over 1200 recombinant proteins, polyclonal antibodies, monoclonal antibodies and ELISA kits for animal health and animal model research. Our products are primarily cytokines, chemokines, interferons, and growth factors. Our product development queue is filled mainly by customer requests. If there is a product that you are looking for and can't find, please send us an email.
Kingfisher Biotech's current portfolio of Oncostatin products, includes bovine and canine recombinant proteins with more in the development queue.
Kingfisher Biotech, Inc. is committed to accelerating basic veterinary research and human disease research done in animal models by developing and commercializing research reagents specific for a variety of species, including bovine, canine, caprine, chicken, dolphin, equine, feline, guinea pig, hamster, human, mouse, ovine, rabbit, rat, swine, and turkey. We will continue to add species as our customer request specific reagents for their research. Currently, we offer over 1200 recombinant proteins, polyclonal antibodies, monoclonal antibodies and ELISA kits for animal health and animal model research. Our products are primarily cytokines, chemokines, interferons, and growth factors. Our product development queue is filled mainly by customer requests. If there is a product that you are looking for and can't find, please send us an email.
Thursday, August 11, 2016
Bovine CXCL10 (IP-10) ELISA VetSet, 2 Plates
The Bovine CXCL10 (IP-10) VetSet (ELISA Development Kit) is for the quantitative determination of bovine CXCL10 (IP-10) in cell culture supernatants.
Kit Contents
Bovine CXCL10 (IP-10) Coated Plate (2 plates)Bovine CXCL10 (IP-10) Standard
Bovine CXCL10 (IP-10) Detection Antibody
Streptavidin-HRP
C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is a member of the C-X-C chemokine family. CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.
Subscribe to:
Posts (Atom)